Dimethyl Sulfoxide → HCID 86624017, compound

Participants

Reaction Conditions

Reaction Steps

DMSO (4.9 mL, 68.8 mml) is added to a solution of oxalyl chloride (4.5 mL, 51.6 mmol) in dry DCM (100 mL) at −78° C. and the mixture is stirred at −78° C. for 10 min. A solution of (R)-2-(4-methoxy-2-vinylbenzyl)-butan-1-ol (5.70, 25.9 mmol) in DCM (30 mL) is added. The mixture is stirred at −78° C. for 15 min and then at −40˜−30° C. for 1 h. Triethylamine (18 mL, 129 mmol) is added slowly. The mixture is stirred at −10˜0° C. for 15 min. The mixture is partitioned between DCM and aq. NH4Cl. The organic extract is dried with MgSO4 and concentrated to give the title compound as an orange oil.

Provenance & Evidence