Allyl bromide → 3,6-Bis-allyloxy-5-nitrobenzo[d]isoxazole

Participants

Reaction Steps

To a suspension of 5-nitrobenzo[d]isoxazole-3,6-diol (1.1 g, 5.61 mmol) and potassium carbonate (3.9 g, 28.2 mmol) in DMF (10 mL) is added dropwise allyl bromide (1.42 mL, 8.30 mmol). The mixture is stirred at room temperature for 18 h. The mixture is diluted with EtOAc, and ice and water are added. The organic phase is separated and washed with water and brine, and dried over MgSO4, filtered and concentrated to afford 3,6-bis-allyloxy-5-nitrobenzo[d]isoxazole as a solid.

Provenance & Evidence