Hydrochloric Acid → HCID 66750829, compound

Participants

Reaction Steps

5-Benzyloxy-6-formylamino-1H-indole-2-carboxylic acid ethyl ester (0.2 g, 0.591 mmol) is suspended in a 9:1 mixture of acetone/water (10 mL). The suspension is treated with 1N HCl (1.8 mL) and brought to reflux for 1 h. The separated solid is filtered, washed with saturated aqueous sodium bicarbonate and water, and air dried for 2 h to afford 6-amino-5-benzyloxy-1H-indole-2-carboxylic acid ethyl ester as a grey solid: (M−H)−=311.

Provenance & Evidence