Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Isoamyl Alcohol | HCID 31260 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 66750779 | HCID 66750779 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Product | HCID 66750773 | HCID 66750773 | — |
Reaction Steps
6-Amino-5-benzyloxy-1H-indole-2-carboxylic acid is suspended in isopentanol (10 mL) and concentrated sulfuric acid (10 drops) is added. The mixture is stirred at 115° C. for 10 min and then stirred at 90° C. for 3 h. Ethyl acetate is added and the mixture is neutralized with saturated sodium bicarbonate. The mixture is then washed with saturated NaCl (3×) and water (1×), dried over MgSO4, filtered, and concentrated to afford 6-amino-5-benzyloxy-1H-indole-2-carboxylic acid 3-methyl-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07700633B2 |
|---|
| Source dataset | uspto-grants-2010_04 |
|---|
| ORD ID | ord-f97b50754b9a41a8b94d6594c89432ff |
|---|
| Source note | uspto-grants-2010_04 |
|---|
