HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbon Dioxide → 6-methyl-1H-indazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | 5-Bromo-6-methyl-1H-indazole | HCID 24729259 | — |
| Reactant | 5-Bromo-6-fluoro-1H-indazole | HCID 46863923 | — |
| Reactant | HCID 178418306 | HCID 178418306 | — |
| Product | 6-methyl-1H-indazole-5-carboxylic acid | HCID 22934040 | — |
Reaction Steps
This compound was prepared in a manner similar to that shown in Scheme 3, using 5-bromo-6-methyl-1H-indazole as the starting material, which was prepared in a manner similar to that of 5-bromo-6-fluoro-1H-indazole. The starting material was treated with t-butyl lithium and carbon dioxide to yield 6-methyl-1H-indazole-5-carboxylic acid, which was in turn treated with thiosemicarbazide and polyphosphoric acid to form 94.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700636B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-505e80425b7145f6bdeb30a6f2056831 |
| Source note | uspto-grants-2010_04 |