反应详情

A solution of sodium 4-hydroxybenzenesulfonate dihydrate (15 g, 64.6 mmol) in 64.66 mL of 1 N aqueous NaOH is heated at reflux for 1 h, cooled and concentrated under vacuum. Toluene is added, and the mixture is again concentrated under vacuum. This process of toluene addition followed by concentration under vacuum is repeated twice more to remove water. The resulting white solid is dried in a vacuum oven at 60° C. overnight to give 4-hydroxybenzenesulfonic acid disodium salt.

1. temperatureat reflux for 1 h
2. temperaturecooled
3. concentrationconcentrated under vacuum
4. additionToluene is added
5. concentrationthe mixture is again concentrated under vacuum
6. additionThis process of toluene addition
7. concentrationfollowed by concentration under vacuum
8. customto remove water
9. customThe resulting white solid is dried in a vacuum oven at 60° C. overnight