Sodium P-phenolsulfonate dihydrate → 4-Hydroxyphenylsulfonic acid disodium salt

HRID 643983Notes

Reaction equation

HRID 643983 reaction equation
O.O.[OH:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([O-:13])(=[O:12])=[O:11])=[CH:6][CH:5]=1.[Na+:14]>[OH-].[Na+]>[Na+:14].[Na+:14].[OH:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([O-:13])(=[O:11])=[O:12])=[CH:6][CH:5]=1.[OH:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([O-:13])(=[O:11])=[O:12])=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 23666329Sodium P-phenolsulfonate dihydrate

Product 1

HCID 195991314-Hydroxyphenylsulfonic acid disodium salt

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of sodium 4-hydroxybenzenesulfonate dihydrate (15 g, 64.6 mmol) in 64.66 mL of 1 N aqueous NaOH is heated at reflux for 1 h, cooled and concentrated under vacuum. Toluene is added, and the mixture is again concentrated under vacuum. This process of toluene addition followed by concentration under vacuum is repeated twice more to remove water. The resulting white solid is dried in a vacuum oven at 60° C. overnight to give 4-hydroxybenzenesulfonic acid disodium salt.

Workup

  1. temperatureat reflux for 1 h
  2. temperaturecooled
  3. concentrationconcentrated under vacuum
  4. additionToluene is added
  5. concentrationthe mixture is again concentrated under vacuum
  6. additionThis process of toluene addition
  7. concentrationfollowed by concentration under vacuum
  8. customto remove water
  9. customThe resulting white solid is dried in a vacuum oven at 60° C. overnight

Sources & evidence

ORD record
ord-469496593bd84f83b17fb8e9f2335d32
Source dataset
uspto-grants-2010_04
Patent number
US07700637B2

Reaction notes

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