Lithium Hydroxide → HCID 59263287, compound

Participants

Reaction Steps

A solution of 1 N aqueous lithium hydroxide (0.78 mL) is added to a solution of the title B compound, 2-(4-phenethylcarbamoyl-benzenesulfonylamino)-benzoic acid methyl ester (113.8 mg, 0.259 mmol) in 4 mL of THF. The reaction is stirred overnight at RT. The solvent is evaporated under a stream of nitrogen, and the residue is partitioned between water (6 mL) and EtOAc. The aqueous layer is washed with EtOAc (1 mL) and then acidified by adding it to a stirred solution of 1 N aqueous HCl (25 mL) to form a white solid. The solid is collected by filtration, washed with water, and dried under vacuum to give 2-(4-phenethylcarbamoyl-benzenesulfonylamino)-benzoic acid: m.p. 242-244° C.; ESI-MS 439.04 [M+1]+.

Provenance & Evidence