Hydrochloric Acid → HCID 59263297, compound

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Reaction Steps

The title D compound, 2-{4-[2-(4-ethoxy-phenyl)-acetylamino]-benzenesulfonyl-amino}-benzoic acid methyl ester (189.1 mg, 0.356 mmol) is dissolved in 4 mL of THF and 1.07 mL of 1 N aqueous lithium hydroxide is added. The mixture is stirred at RT for 3 days and is then concentrated under a stream of nitrogen. The residue is taken up in warm water (20 mL) to give a clear solution. The solution is added slowly to 30 mL of 1 N aqueous HCl. The resulting precipitate is collected by filtration, washed with water, and dried under vacuum to give 2-{4-[2-(4-ethoxy-phenyl)-acetylamino]benzenesulfonylamino}benzoic acid: m.p. 241-242° C.: ESI-MS 455 [M+1]+.

Provenance & Evidence