反应详情

To a suspension of 300 mg of {4-amino-1-[(benzyloxy)carbonyl]piperidin-4-yl}acetic acid in 6 ml of methanol was added 150 μl of thionyl chloride, followed by stirring for 2 days. The reaction mixture was concentrated under reduced pressure, ether was added thereto, and the resulting solid was collected by filtration and dried to obtain 350 mg of benzyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate hydrochloride.

1. concentrationThe reaction mixture was concentrated under reduced pressure, ether
2. additionwas added
3. filtrationthe resulting solid was collected by filtration
4. customdried