Hydrochloric Acid → T-2307

Participants

Reaction Conditions

Reaction Steps

To a water (40 mL)/2-propanol (80 mL) suspension of 20.0 g of 4-{3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidine was added 14.3 g of hydrochloric acid, which was then stirred at 60° C. for 10 minutes. Thereto was added 120 mL of 2-propanol, to which 100 mg of seed crystals were added, followed by stirring at room temperature for 35 minutes and under cooling with ice for 2 hours. The precipitated crystals were collected by filtration to provide 28.3 g of 4-{3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidine trihydrochloride pentahydrate as colorless crystals.

Provenance & Evidence