HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 64414Generated: October 29, 2026
Ethyl 4-piperidinecarboxylate → ethyl 1-{(2R)-2-[(tert-butoxycarbonyl)amino]-2-phenylethyl}piperidine-4-carboxylate
https://huagongshe.com/reaction/64414
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | N-[(1R)-2-[(Methylsulfonyl)oxy]-1-phenylethyl]carbamic acid 1,1-dimethylethyl ester | HCID 11723227 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | ethyl 1-{(2R)-2-[(tert-butoxycarbonyl)amino]-2-phenylethyl}piperidine-4-carboxylate | HCID 86713423 | — |
Reaction Steps
To a solution of 1 g of (2R)-2-[(tert-butoxycarbonyl)amino]-2-phenylethyl methanesulfonate in 5 mL of THF were added 0.4 mL of ethyl piperidine-4-carboxylate and 1 mL of diisopropylethylamine, followed by stirring at 70° C. for 14 hours, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 160 mg of ethyl 1-{(2R)-2-[(tert-butoxycarbonyl)amino]-2-phenylethyl}piperidine-4-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09447090B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-af5fd94627284af28a31a379107a2c06 |
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| Source note | uspto-grants-2016_09 |
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