Propionic Acid → HCID 86625842, compound

Participants

Reaction Steps

To an N-methyl-2-pyrrolidone (10 mL) solution of 0.35 g of propionic acid was added 0.76 g of 1,1′-carbonyldiimidazole at room temperature, which was then stirred at the same temperature for one hour. An N-methyl-2-pyrrolidone (10 mL) solution of 1.00 g of 4-{3-[4-(3-{4-[amino(hydroxyimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamide=oxime was added to the mixture at room temperature, which was then stirred for 15 hours. The reaction mixture was added to a mixture of chloroform and water. The precipitate was collected by filtration and washed with ethyl acetate to provide 0.58 g of 4-{3-[4-(3-{4-[amino(propionyloxyimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamide=O-(propionyl)oxime as white solid form.

Provenance & Evidence