Butyric Acid → HCID 86625844, compound

Participants

Reaction Steps

To an N-methyl-2-pyrrolidone (10 mL) solution of 0.42 g of butyric acid was added 0.76 g of 1,1′-carbonyldiimidazole at room temperature, which was then stirred at the same temperature for one hour. An N-methyl-2-pyrrolidone (10 mL) solution of 1.00 g of 4-{3-[4-(3-{4-[amino(hydroxyimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamide=oxime was added to the mixture at room temperature, which was then stirred at the same temperature for 14 hours. The reaction mixture was added to a mixture of ethyl acetate and water. The precipitate was collected by filtration and washed with ethyl acetate to provide 1.10 g of 4-{3-[4-(3-{4-[amino(n-butyloxyimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamide=O-(butyryl)oxime as white solid form.

Provenance & Evidence