反应详情

To 223 mg of tert-butyl (2E)-3-(4-cyanophenyl)acrylate were added 12 mL of methanol, 5 ml of THF, 1 ml of an acetic acid solution, and 90 mg of 10% palladium-carbon in this order, followed by stirring for 3 hours under hydrogen at 3 atm. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. To the residue were added a saturated aqueous sodium hydrogen carbonate solution and ethyl acetate to carry out a layer separation operation. The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to obtain 177 mg of tert-butyl 3-[4-(aminomethyl)phenyl]propanoate.

1. customThe catalyst was removed by filtration
2. concentrationthe filtrate was concentrated under reduced pressure
3. additionTo the residue were added a saturated aqueous sodium hydrogen carbonate solution and ethyl acetate
4. customa layer separation operation
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. customthe solvent was evaporated under reduced pressure