Pyridine → HCID 57890277, compound

Participants

Reaction Conditions

Reaction Steps

3-(3,4-Dimethoxy-phenyl)-7-hydroxy-8-methylchromen-4-one (94.8 g) was suspended in acetic anhydride (450 mL) under a nitrogen atmosphere. Pyridine (23 mL) was added and the reaction mixture was heated to reflux for 1 hour. The pot was cooled overnight at −18° C. to produce a crystalline solid within the reaction mixture. This was filtered and the solid was washed with the filtrate and additional water (500 mL) to yield a brown solid. Further washing with ethanol produced a white crystalline solid. The solid was dried overnight in a desiccator to yield 7-acetoxy-3-(3,4-dimethoxyphenyl)-8-methylchromen-4-one (44.7 g, 42%).

Provenance & Evidence