HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[4-(N,N-Dimethylamino)-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-benzoylamino]-N-(5-chloropyridin-2-yl)benzamide → N-(5-chloropyridin-2-yl)-2-[4-(N,N-dimethylamino)-2-(piperidin-4-yloxy)benzoylamino]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[4-(N,N-Dimethylamino)-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-benzoylamino]-N-(5-chloropyridin-2-yl)benzamide | HCID 68533953 | — |
| Solvent | Ethyl ether methylene chloride | HCID 21881112 | — |
| Product | N-(5-chloropyridin-2-yl)-2-[4-(N,N-dimethylamino)-2-(piperidin-4-yloxy)benzoylamino]benzamide | HCID 57860759 | 60% |
Reaction Steps
Using a procedure similar to Example 1-G, 2-[4-(N,N-dimethylamino)-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide gave the desired product (638 mg, 60%) as a white solid after chromatography and CH2Cl2/ether trituration.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-85daf07d1c694cdf85a1cacfa62a698c |
| Source note | uspto-grants-2010_04 |