HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-(1-tert-Butoxycarbonylpiperidin-4-yloxy)-4-fluorobenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Methyl 2-(1-tert-Butoxycarbonylpiperidin-4-yloxy)-4-fluorobenzoate | HCID 57602502 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(1-tert-Butoxycarbonylpiperidin-4-yloxy)-4-fluorobenzoic acid | HCID 57602439 | 76.1% |
Reaction Steps
A mixture of methyl-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-fluorobenzoate (3.05 g, 8.64 mmol), 1 M aq LiOH (15 mL, 15 mmol), MeOH (15 mL), and THF (45 mL) was stirred overnight. The reaction was diluted with EtOAc, washed with satd citric acid, dried over MgSO4, concentrated, and triturated with ether to give the desired product as a white solid (2.23 g, 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-b25a0d8f4e14403d91e7a5fd614469da |
| Source note | uspto-grants-2010_04 |