HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 644173Generated: October 26, 2026
Piperidine → 2-[4-(piperidin-1-yl)-2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide
https://huagongshe.com/reaction/644173
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2-[4-Fluoro-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide | HCID 68530207 | — |
| Product | 2-[4-(piperidin-1-yl)-2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide | HCID 57860869 | 44% |
Reaction Steps
Using methods substantially equivalent to those described in example 4-F except that the reaction was heated to 106° C., 2-[4-(piperidin-1-yl)-2-(1-tert-butoxycarbonyl-piperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide (200 mg, 0.32 mmol, 44%) was prepared from 2-[4-fluoro-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-benzoylamino]-N-(5-chloropyridin-2-yl)benzamide and piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07700628B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-bdad8d63eb9c4995a290361eb616064b |
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| Source note | uspto-grants-2010_04 |
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