HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-tert-butyl-2-(1-Boc-piperidin-4-yloxy)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-(N-Boc-piperidine-4-yloxy)-4-(tert-butyl)benzoic acid | HCID 68530505 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-tert-butyl-2-(1-Boc-piperidin-4-yloxy)benzoyl chloride | HCID 86610260 | — |
Reaction Steps
To a stirring solution of 4-(tert-butyl)-2-(1-Boc-piperidin-4-yloxy)benzoic acid (4.0 g, 10.6 mmol) in dichloromethane (20 mL) at 0° C., was added oxalyl chloride (13 mmol), followed by a small amount of DMF. After 30 min, the solvents were removed in vacuo and the residue was dissolved in dichloromethane to make a solution of the title compound, approximately 0.1 g/mL.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-71598a3e9d2045fca5470bf1a8c972f4 |
| Source note | uspto-grants-2010_04 |