Citric Acid → HCID 68530977, compound

Participants

Reaction Steps

A mixture of methyl 2-(2-tert-butoxycarbonylaminoethoxy)-4-fluorobenzoate (4.2 g, 13.4 mmol), THF (100 mL), and MeOH (50 mL) was treated with 1 M lithium hydroxide (16 mL) and stirred for 48 hours at ambient temperature. The reaction was acidified with 10% aqueous citric acid (50 mL), diluted with brine (100 mL), and extracted with EtOAc (3×100 mL). The combined organic layers were dried over MgSO4 and concentrated to give 3.93 g (13.1 mmol, 98%) of a white solid.

Provenance & Evidence