2-Amino-5-chloro-N-(5-chloropyridin-2-yl)benzamide → HCID 68530733, compound

HRID 644196Notes

Reaction equation

HRID 644196 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:18])[C:10]2[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=2[NH2:17])=[N:6][CH:7]=1.[C:19]([O:23][C:24]([NH:26][CH2:27][CH2:28][O:29][C:30]1[CH:38]=[C:37]([F:39])[CH:36]=[CH:35][C:31]=1[C:32](O)=[O:33])=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:19]([O:23][C:24]([NH:26][CH2:27][CH2:28][O:29][C:30]1[CH:38]=[C:37]([F:39])[CH:36]=[CH:35][C:31]=1[C:32]([NH:17][C:11]1[CH:12]=[CH:13][C:14]([Cl:16])=[CH:15][C:10]=1[C:9]([NH:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][N:6]=1)=[O:18])=[O:33])=[O:25])([CH3:22])([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 219064182-Amino-5-chloro-N-(5-chloropyridin-2-yl)benzamideHCID 68530977HCID 68530977, compound

Product 1

HCID 68530733HCID 68530733, compoundYield 75%

Procedure

Using methods substantially equivalent to those described in Example 29-G, the compound was prepared in a 75% yield from N-(5-chloropyridin-2-yl)-2-amino-5-chloro-benzamide and 2-(2-tert-butoxycarbonylaminoethoxy)-4-fluorobenzoic acid.

Sources & evidence

ORD record
ord-2e520959e15742a698febba7417022e3
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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