HCID 86634201, compound → HCID 68534234, compound

HRID 644199Notes

Reaction equation

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].ClC1C=CC(NC(=O)C2C=C(F)C=CC=2)=NC=1.C(O[CH:30]([N:65]=C=O)[CH2:31][O:32][C:33]1[CH:58]=[C:57]([N:59]2[CH2:64][CH2:63][O:62][CH2:61][CH2:60]2)[CH:56]=[CH:55][C:34]=1[C:35]([NH:37][C:38]1[CH:53]=[CH:52][C:51]([F:54])=[CH:50][C:39]=1[C:40]([NH:42][C:43]1[CH:48]=[CH:47][C:46]([Cl:49])=[CH:45][N:44]=1)=[O:41])=[O:36])(C)(C)C>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH2:65][CH2:30][CH2:31][O:32][C:33]1[CH:58]=[C:57]([N:59]2[CH2:64][CH2:63][O:62][CH2:61][CH2:60]2)[CH:56]=[CH:55][C:34]=1[C:35]([NH:37][C:38]1[CH:53]=[CH:52][C:51]([F:54])=[CH:50][C:39]=1[C:40]([NH:42][C:43]1[CH:48]=[CH:47][C:46]([Cl:49])=[CH:45][N:44]=1)=[O:41])=[O:36]

Participants

Reactant 2

HCID 86634201HCID 86634201, compound

HCID 86634202HCID 86634202, compound

Product 1

HCID 68534234HCID 68534234, compoundYield 74%

Procedure

Using methods substantially equivalent to those described in Example 34, 2-2-(2-aminoethoxy)-4-(morpholin-4-yl)benzoylamino]-N-(5-chloropyridin-2-yl)-5-fluorobenzamide trifluoroacetate was prepared in a 74% yield from 2-[2-(2-tert-butoxy-carbonylaminoethoxy)-4-(morpholin-4-yl)benzoylamino]-N-(5-chloropyridin-2-yl)-5-fluorobenzamide.

Sources & evidence

ORD record: ord-e4c59a35d70e492eaa630e92e1bdedf8
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07700628B2

Reaction notes

Loading…