HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic acid, 2,4-difluoro-, ethyl ester → HCID 68532439, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic acid, 2,4-difluoro-, ethyl ester | HCID 2737170 | — |
| Reactant | Tert-butyl (3-hydroxy-2-methylpropyl)carbamate | HCID 11424042 | — |
| Reactant | Ethyl-2-(3-tert-butoxycarbonylamino-2-methylpropoxy)-4-fluorobenzoate | HCID 68535248 | — |
| Product | HCID 68532439 | HCID 68532439 | 7% |
Reaction Steps
Using methods substantially equivalent to those described in Example 21-C, ethyl-2-(3-tert-butoxycarbonylamino-2-methylpropoxy)-4-fluorobenzoate was prepared from ethyl-2,4-difluorobenzoate and 2-methyl-3-tert-butoxycarbonylaminopropanol. The impure material was saponified using methods substantially equivalent to those described in Example 21-D to give 2-(3-tert-butoxycarbonylamino-2-methylpropoxy)-4-fluoro-benzoic acid (554 mg, 1.69 mmol, 7% for 2 steps after RPHPLC purification).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-ae26553120e44b08ae648ae5ba6e7c9f |
| Source note | uspto-grants-2010_04 |