HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 68532453, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Methyl 4-(benzyloxy)-2-hydroxybenzoate | HCID 225489 | — |
| Reactant | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| Product | HCID 68532453 | HCID 68532453 | — |
Reaction Steps
Using methods substantially equivalent to those described in Example 1-C, methyl 4-benzyloxy-2-hydroxybenzoate (2.0 g, 8.1 mmol), N-tert-butoxycarbonyl-4-hydroxy-piperidine (1.6 g, 8.1 mmol), triphenylphosphine (2.1 g, 8.1 mmol), and diethyl azodicarboxyalte (1.3 mL, 8.1 mmol) afforded, after purification by chromatography (SiO2: 5 to 15% EtOAc in hexanes), 2.57 g (74%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-e600a6fec53d40f381972030ffe8d9c5 |
| Source note | uspto-grants-2010_04 |