HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 4-isopropyl-2-methoxymethoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 4-Isopropyl-2-methoxymethoxybenzoic acid | HCID 68532278 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | Methyl 4-isopropyl-2-methoxymethoxybenzoate | HCID 68533886 | — |
Reaction Steps
Into methylene chloride (40 mL) was dissolved 4-isopropyl-2-methoxymethoxy-benzoic acid (6.0 g, 26.8 mmol). Methanol (10 mL) was added, followed by the dropwise addition of 2 M hexane solution of trimethylsilyldiazomethane (14.7 mL). After 2 h, HOAc (0.5 mL) was added and the solvent was removed under vacuum, giving the title compound as an oil, which was used in next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-d11ef92e482541bb958da1018f73d6b8 |
| Source note | uspto-grants-2010_04 |