Hydrochloric Acid → HCID 68535627, compound

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Reaction Steps

A solution of methyl 2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(4-chloro-phenyl)benzoate (0.3 g 0.67 mmol) in dioxane (10 mL) and aqueous NaOH (2 g in 10 mL H2O) was heated at reflux for 4 h. The reaction was then cooled to room temperature, acidified to pH 3 with 1 N HCl, and extracted with ethyl acetate (3×50 mL). The organic layers were combined, dried over magnesium sulfate, filtered, and concentrated in vacuo to give 0.293 g of product (100%).

Provenance & Evidence