反应详情

温度

70 °C

A solution of methyl 5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzoate (7.8 g, 17 mmol) in EtOH (100 mL) and water (100 mL) was treated with KOH (4.8 g, 85 mmol) and stirred at 70° C. for 1 hour. The reaction was concentrated under vacuum, quenched with glacial acetic acid (5.1 g), and allowed to stand at ambient temperature for crystallization. The solid was filtered to recover 7.4 g (98%).

1. concentrationThe reaction was concentrated under vacuum
2. customquenched with glacial acetic acid (5.1 g)
3. customto stand at ambient temperature for crystallization
4. filtrationThe solid was filtered
5. customto recover 7.4 g (98%)