反应详情

Using methods substantially equivalent to those described in Example 60-I and J, 5-chloro-N-(5-chloropyridin-2-yl)-2-[4-isopropyl-2-(piperidin-3-ylmethoxy)-benzoylamino]benzamide trifluoroacetate (150 mg, 0.20 mmol, 6%) was prepared from 2-(N-tert-butoxycarbonylpiperidin-3-yl)-4-isopropylmethoxybenzoic acid and N-(5-chloropyridin-2-yl)-2-amino-5-chlorobenzamide. This product was subjected to reverse phase HPLC to obtain 60 mg of the title compound as the hydrochloride salt.