2-amino-N-(5-chloropyridin-2-yl)-5-fluorobenzamide → 2-[2-(3-tert-Butoxycarbonylaminopropoxy)-4-(methylthio)benzoylamino]-N-(5-chloropyridin-2-yl)-5-fluorobenzamide

HRID 644241Notes

Reaction equation

HRID 644241 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:21]=[C:20]([S:22][CH3:23])[CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:24][C:25]1[CH:26]=[CH:27][C:28]([NH:31][C:32](=[O:41])[C:33]2[CH:38]=[C:37]([F:39])[CH:36]=[CH:35][C:34]=2[NH2:40])=[N:29][CH:30]=1>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][O:12][C:13]1[CH:21]=[C:20]([S:22][CH3:23])[CH:19]=[CH:18][C:14]=1[C:15]([NH:40][C:34]1[CH:35]=[CH:36][C:37]([F:39])=[CH:38][C:33]=1[C:32]([NH:31][C:28]1[CH:27]=[CH:26][C:25]([Cl:24])=[CH:30][N:29]=1)=[O:41])=[O:17])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 219063152-amino-N-(5-chloropyridin-2-yl)-5-fluorobenzamideHCID 579365402-(3-Tert-butoxycarbonylaminopropoxy)-4-(methylthio)benzoic acid

Product 1

HCID 685329522-[2-(3-tert-Butoxycarbonylaminopropoxy)-4-(methylthio)benzoylamino]-N-(5-chloropyridin-2-yl)-5-fluorobenzamide

Procedure

2-[2-(3-tert-Butoxycarbonylaminopropoxy)-4-(methylthio)benzoylamino]-N-(5-chloropyridin-2-yl)-5-fluorobenzamide was prepared by methods described in Example 4-E from 2-(3-tert-butoxycarbonylaminopropoxy)-4-(methylthio)benzoic acid and N-(5-chloropyridin-2-yl)-2-amino-5-fluorobenzamide (1.53 g, 47%).

Sources & evidence

ORD record
ord-8d7f93063c5c464a91afec9e27befb84
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

Loading…