Hydrochloric Acid → HCID 68532946, compound

Participants

Reaction Steps

To a solution of N-(5-chloropyridin-2-yl)-2-[2-(methoxymethoxy)-4-(2-methyl-1,3-dioxolan-2-yl)benzoylamino]benzamide (4.37 g, 8.78 mmol) in THF (150 mL) at 0° C. was added 5 N HCl (28 mL, 140 mmol). The resulting solution was stirred at room temperature for 6 h. The solution was concentrated to the half of its original volume, diluted with H2O (300 mL) and basified with 2 N NaOH (˜pH 9). The solid obtained was filtered, washed with H2O (3×50 mL), and dried to give the expected product (3.82 g, 96%),

Provenance & Evidence