HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-amino-N-(5-chloropyridin-2-yl)-5-fluorobenzamide → 2-[2-[3-(Tert-butoxycarbonylamino)propoxy]-4-(morpholin-4-yl)benzoylamino]-n-(5-chloropyridin-2-yl)-5-fluorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-amino-N-(5-chloropyridin-2-yl)-5-fluorobenzamide | HCID 21906315 | — |
| Reactant | 2-(3-tert-Butoxycarbonylaminopropoxy)-4-(morpholin-4-yl)benzoic Acid | HCID 57602500 | — |
| Product | 2-[2-[3-(Tert-butoxycarbonylamino)propoxy]-4-(morpholin-4-yl)benzoylamino]-n-(5-chloropyridin-2-yl)-5-fluorobenzamide | HCID 68535389 | 70% |
Reaction Steps
Using a procedure analogous to Example 4-C, 2-[3-(tert-butoxycarbonylamino)-propoxy]-4-(morpholin-4-yl)benzoic acid and N-(5-chloropyridin-2-yl)-2-amino-5-fluorobenzamide gave the desired product as a solid (2.56 g, 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-6336ace354164d2cb850725a4dcd644d |
| Source note | uspto-grants-2010_04 |