HRID644254

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID77887

3-Nitropyridin-2-ylamine

C5H5N3O2

结构：CN1CCC(Oc2cc(N3CCCC3)ccc2-c2nc3ccc(F)cc3c(=O)o2)CC1

HCID57860842

未命名化合物

结构：CN1CCC(Oc2cc(N3CCCC3)ccc2C(=O)Nc2ccc(F)cc2C(=O)Nc2ncccc2[N+](=O)[O-])CC1.Cl

HCID68532907

未命名化合物

PRODUCTS

生成物

结构：CN1CCC(Oc2cc(N3CCCC3)ccc2C(=O)Nc2ccc(F)cc2C(=O)Nc2ncccc2[N+](=O)[O-])CC1

HCID57860841

未命名化合物

PROCEDURE

实验过程

Using methods substantially equivalent to those described in Example 118, 5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-N-(3-nitro-pyridin-2-yl)benzamide hydrochloride was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 2-amino-3-nitro-pyridine.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7ec737d003a04eeca340e52d70ec6f32
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07700628B2
来源说明: uspto-grants-2010_04

反应 SMILES

Cl.[F:2][C:3]1[CH:4]=[CH:5][C:6]([NH:21][C:22](=[O:42])[C:23]2[CH:28]=[CH:27][C:26]([N:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)=[CH:25][C:24]=2[O:34][CH:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)=[C:7]([CH:20]=1)[C:8]([NH:10][C:11]1[C:16]([N+:17]([O-:19])=[O:18])=[CH:15][CH:14]=[CH:13][N:12]=1)=[O:9].FC1C=CC2N=C(C3C=CC(N4CCCC4)=CC=3OC3CCN(C)CC3)OC(=O)C=2C=1.NC1C([N+]([O-])=O)=CC=CN=1>>[F:2][C:3]1[CH:4]=[CH:5][C:6]([NH:21][C:22](=[O:42])[C:23]2[CH:28]=[CH:27][C:26]([N:29]3[CH2:30][CH2:31][CH2:32][CH2:33]3)=[CH:25][C:24]=2[O:34][CH:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)=[C:7]([CH:20]=1)[C:8]([NH:10][C:11]1[C:16]([N+:17]([O-:19])=[O:18])=[CH:15][CH:14]=[CH:13][N:12]=1)=[O:9]