4-Nitroaniline → HCID 68534335, compound

HRID 644255Notes

Reaction equation

HRID 644255 reaction equation
Cl.[F:2][C:3]1[CH:4]=[CH:5][C:6]([NH:21][C:22](=[O:42])[C:23]2[CH:28]=[CH:27][C:26]([N:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)=[CH:25][C:24]=2[O:34][CH:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)=[C:7]([CH:20]=1)[C:8]([NH:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=1)=[O:9].FC1C=CC2N=C(C3C=CC(N4CCCC4)=CC=3OC3CCN(C)CC3)OC(=O)C=2C=1.[N+](C1C=CC(N)=CC=1)([O-])=O>>[F:2][C:3]1[CH:4]=[CH:5][C:6]([NH:21][C:22](=[O:42])[C:23]2[CH:28]=[CH:27][C:26]([N:29]3[CH2:30][CH2:31][CH2:32][CH2:33]3)=[CH:25][C:24]=2[O:34][CH:35]2[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]2)=[C:7]([CH:20]=1)[C:8]([NH:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=1)=[O:9]

Participants

4

Reactant 3

HCID 74754-NitroanilineHCID 578608426-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-oneHCID 686942025-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-N-(4-nitro-phenyl)benzamide hydrochloride

Product 1

HCID 68534335HCID 68534335, compound

Procedure

Using methods substantially equivalent to those described in Example 118, 5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-N-(4-nitro-phenyl)benzamide hydrochloride was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 4-nitroaniline.

Sources & evidence

ORD record
ord-2565a7b7a66e46f89cec94677e77e1c0
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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