p-Aminoacetophenone → N-(4-Acetylphenyl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide
Reaction equation
FC(F)(F)C(O)=O.[C:8]([C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:48])[C:19]2[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=2[NH:26][C:27](=[O:47])[C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:38][CH2:37][CH2:36][CH2:35]3)=[CH:30][C:29]=2[O:39][CH:40]2[CH2:45][CH2:44][N:43]([CH3:46])[CH2:42][CH2:41]2)=[CH:13][CH:12]=1)(=[O:10])[CH3:9].FC1C=CC2N=C(C3C=CC(N4CCCC4)=CC=3OC3CCN(C)CC3)OC(=O)C=2C=1.C(C1C=CC(N)=CC=1)(=O)C>>[C:8]([C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:48])[C:19]2[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=2[NH:26][C:27](=[O:47])[C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:35][CH2:36][CH2:37][CH2:38]3)=[CH:30][C:29]=2[O:39][CH:40]2[CH2:41][CH2:42][N:43]([CH3:46])[CH2:44][CH2:45]2)=[CH:13][CH:12]=1)(=[O:10])[CH3:9]Participants
4
Reactant 3
Product 1
Procedure
Using methods substantially equivalent to those described in Example 118, N-(4-acetylphenyl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)-benzoylamino]benzamide trifluoroacetate was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 4-acetylaniline.
Sources & evidence
- ORD record
- ord-eb70fcfef5d741beaa1cd01bd2cddc1b
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07700628B2
Reaction notes
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