HRID644256

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7468

4-Aminoacetophenone

C8H9NO

结构：CN1CCC(Oc2cc(N3CCCC3)ccc2-c2nc3ccc(F)cc3c(=O)o2)CC1

HCID57860842

未命名化合物

结构：CC(=O)c1ccc(NC(=O)c2cc(F)ccc2NC(=O)c2ccc(N3CCCC3)cc2OC2CCN(C)CC2)cc1.O=C(O)C(F)(F)F

HCID68535725

未命名化合物

PRODUCTS

生成物

结构：CC(=O)c1ccc(NC(=O)c2cc(F)ccc2NC(=O)c2ccc(N3CCCC3)cc2OC2CCN(C)CC2)cc1

HCID57860902

未命名化合物

PROCEDURE

实验过程

Using methods substantially equivalent to those described in Example 118, N-(4-acetylphenyl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)-benzoylamino]benzamide trifluoroacetate was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 4-acetylaniline.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eb70fcfef5d741beaa1cd01bd2cddc1b
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07700628B2
来源说明: uspto-grants-2010_04

反应 SMILES

FC(F)(F)C(O)=O.[C:8]([C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:48])[C:19]2[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=2[NH:26][C:27](=[O:47])[C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:38][CH2:37][CH2:36][CH2:35]3)=[CH:30][C:29]=2[O:39][CH:40]2[CH2:45][CH2:44][N:43]([CH3:46])[CH2:42][CH2:41]2)=[CH:13][CH:12]=1)(=[O:10])[CH3:9].FC1C=CC2N=C(C3C=CC(N4CCCC4)=CC=3OC3CCN(C)CC3)OC(=O)C=2C=1.C(C1C=CC(N)=CC=1)(=O)C>>[C:8]([C:11]1[CH:16]=[CH:15][C:14]([NH:17][C:18](=[O:48])[C:19]2[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=2[NH:26][C:27](=[O:47])[C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:35][CH2:36][CH2:37][CH2:38]3)=[CH:30][C:29]=2[O:39][CH:40]2[CH2:41][CH2:42][N:43]([CH3:46])[CH2:44][CH2:45]2)=[CH:13][CH:12]=1)(=[O:10])[CH3:9]