3,5-Dichloropyridine → HCID 57860859, compound

HRID 644257Notes

Reaction equation

HRID 644257 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[C:10]([NH:16][C:17](=[O:47])[C:18]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=2[NH:25][C:26](=[O:46])[C:27]2[CH:32]=[CH:31][C:30]([N:33]3[CH2:37][CH2:36][CH2:35][CH2:34]3)=[CH:29][C:28]=2[O:38][CH:39]2[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]2)=[N:11][CH:12]=[C:13]([Cl:15])[CH:14]=1.FC1C=CC2N=C(C3C=CC(N4CCCC4)=CC=3OC3CCN(C)CC3)OC(=O)C=2C=1.ClC1C=NC=C(Cl)C=1>>[Cl:8][C:9]1[C:10]([NH:16][C:17](=[O:47])[C:18]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=2[NH:25][C:26](=[O:46])[C:27]2[CH:32]=[CH:31][C:30]([N:33]3[CH2:34][CH2:35][CH2:36][CH2:37]3)=[CH:29][C:28]=2[O:38][CH:39]2[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]2)=[N:11][CH:12]=[C:13]([Cl:15])[CH:14]=1

Participants

4

Reactant 3

HCID 171533,5-DichloropyridineHCID 578608426-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-oneHCID 86634209HCID 86634209, compound

Product 1

HCID 57860859HCID 57860859, compound

Procedure

Using methods substantially equivalent to those described in Example 118, N-(3,5-dichloropyridin-2-yl)-5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide trifluoroacetate was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 3,5-dichloro-pyridine.

Sources & evidence

ORD record
ord-06541405609743af887febbb784bfff0
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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