2-Amino-3-methylpyridine → HCID 57860798, compound

HRID 644258Notes

Reaction equation

HRID 644258 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:10]=[CH:11][C:12]([NH:25][C:26](=[O:46])[C:27]2[CH:32]=[CH:31][C:30]([N:33]3[CH2:37][CH2:36][CH2:35][CH2:34]3)=[CH:29][C:28]=2[O:38][CH:39]2[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]2)=[C:13]([CH:24]=1)[C:14]([NH:16][C:17]1[C:22]([CH3:23])=[CH:21][CH:20]=[CH:19][N:18]=1)=[O:15].FC1C=CC2N=C(C3C=CC(N4CCCC4)=CC=3OC3CCN(C)CC3)OC(=O)C=2C=1.NC1C(C)=CC=CN=1>>[F:8][C:9]1[CH:10]=[CH:11][C:12]([NH:25][C:26](=[O:46])[C:27]2[CH:32]=[CH:31][C:30]([N:33]3[CH2:37][CH2:36][CH2:35][CH2:34]3)=[CH:29][C:28]=2[O:38][CH:39]2[CH2:40][CH2:41][N:42]([CH3:45])[CH2:43][CH2:44]2)=[C:13]([CH:24]=1)[C:14]([NH:16][C:17]1[C:22]([CH3:23])=[CH:21][CH:20]=[CH:19][N:18]=1)=[O:15]

Participants

4

Reactant 3

HCID 153472-Amino-3-methylpyridineHCID 578608426-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-oneHCID 86634210HCID 86634210, compound

Product 1

HCID 57860798HCID 57860798, compound

Procedure

Using methods substantially equivalent to those described in Example 118, 5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-N-(3-methylpyridin-2-yl)benzamide trifluoroacetate was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 2-amino-3-methylpyridine.

Sources & evidence

ORD record
ord-37cfb9de796c4d5a82714d82851581fc
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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