4-Methoxy-2-nitroaniline → HCID 57860805, compound

HRID 644260Notes

Reaction equation

HRID 644260 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:10]=[CH:11][C:12]([NH:29][C:30](=[O:50])[C:31]2[CH:36]=[CH:35][C:34]([N:37]3[CH2:41][CH2:40][CH2:39][CH2:38]3)=[CH:33][C:32]=2[O:42][CH:43]2[CH2:48][CH2:47][N:46]([CH3:49])[CH2:45][CH2:44]2)=[C:13]([CH:28]=1)[C:14]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][C:18]=1[N+:25]([O-:27])=[O:26])=[O:15].FC1C=CC2N=C(C3C=CC(N4CCCC4)=CC=3OC3CCN(C)CC3)OC(=O)C=2C=1.COC1C=CC(N)=C([N+]([O-])=O)C=1>>[F:8][C:9]1[CH:10]=[CH:11][C:12]([NH:29][C:30](=[O:50])[C:31]2[CH:36]=[CH:35][C:34]([N:37]3[CH2:41][CH2:40][CH2:39][CH2:38]3)=[CH:33][C:32]=2[O:42][CH:43]2[CH2:44][CH2:45][N:46]([CH3:49])[CH2:47][CH2:48]2)=[C:13]([CH:28]=1)[C:14]([NH:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][C:18]=1[N+:25]([O-:27])=[O:26])=[O:15]

Participants

4

Reactant 3

HCID 667934-Methoxy-2-nitroanilineHCID 578608426-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-oneHCID 86634211HCID 86634211, compound

Product 1

HCID 57860805HCID 57860805, compound

Procedure

Using methods substantially equivalent to those described in Example 118, 5-fluoro-N-(4-methoxy-2-nitrophenyl)-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]benzamide trifluoroacetate was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 4-methoxy-2-nitroaniline.

Sources & evidence

ORD record
ord-989611f283d647ddaec80d735493f9ec
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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