2-Methoxyaniline → HCID 57860915, compound

HRID 644263Notes

Reaction equation

HRID 644263 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:10]=[CH:11][C:12]([NH:26][C:27](=[O:47])[C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:38][CH2:37][CH2:36][CH2:35]3)=[CH:30][C:29]=2[O:39][CH:40]2[CH2:45][CH2:44][N:43]([CH3:46])[CH2:42][CH2:41]2)=[C:13]([CH:25]=1)[C:14]([NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][CH3:24])=[O:15].FC1C=CC2N=C(C3C=CC(N4CCCC4)=CC=3OC3CCN(C)CC3)OC(=O)C=2C=1.COC1C=CC=CC=1N>>[F:8][C:9]1[CH:10]=[CH:11][C:12]([NH:26][C:27](=[O:47])[C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:38][CH2:37][CH2:36][CH2:35]3)=[CH:30][C:29]=2[O:39][CH:40]2[CH2:41][CH2:42][N:43]([CH3:46])[CH2:44][CH2:45]2)=[C:13]([CH:25]=1)[C:14]([NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][CH3:24])=[O:15]

Participants

4

Reactant 3

HCID 70002-MethoxyanilineHCID 578608426-Fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)phenyl]-4H-3,1-benzoxazin-4-oneHCID 86634213HCID 86634213, compound

Product 1

HCID 57860915HCID 57860915, compound

Procedure

Using methods substantially equivalent to those described in Example 118, 5-fluoro-2-[2-(1-methylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoylamino]-N-(2-methoxyphenyl)benzamide trifluoroacetate was prepared from 6-fluoro-2-[4-(pyrrolidin-1-yl)-2-(1-methylpiperidin-4-yloxy)phenyl]-4H-3,1-benzoxazin-4-one and 2-methoxyaniline.

Sources & evidence

ORD record
ord-9a8c41fa71984b12a7228042883d5466
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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