tert-butyl N-(3-hydroxypropyl)carbamate → HCID 57936574, compound

HRID 644269Notes

Reaction equation

HRID 644269 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([S:12][CH2:13][CH3:14])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][CH2:25]O)=[O:21])([CH3:18])([CH3:17])[CH3:16]>>[C:15]([O:19][C:20]([NH:22][CH2:23][CH2:24][CH2:25][O:1][C:2]1[CH:11]=[C:10]([S:12][CH2:13][CH3:14])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5])=[O:21])([CH3:18])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 3838134tert-butyl N-(3-hydroxypropyl)carbamateHCID 57936526HCID 57936526, compound

Product 1

HCID 57936574HCID 57936574, compoundYield 85%

Procedure

Using a procedure analogous to Example 21-C, methyl 2-hydroxy-4-(ethylthio)-benzoate and 3-t-butoxycarbonylaminopropanol gave the title compound as a solid (10.41 g, 85%).

Sources & evidence

ORD record
ord-ec2517416be14dbe98d6189d046afc1b
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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