HCID 21906330, compound → HCID 68532681, compound

HRID 644270Notes

Reaction equation

HRID 644270 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:18])[C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[NH2:17])=[N:6][CH:7]=1.[CH2:19]([S:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](O)=[O:27])=[C:24]([O:31][CH2:32][CH2:33][CH2:34][NH:35][C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])[CH:23]=1)[CH3:20]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:18])[C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=2[NH:17][C:26](=[O:27])[C:25]2[CH:29]=[CH:30][C:22]([S:21][CH2:19][CH3:20])=[CH:23][C:24]=2[O:31][CH2:32][CH2:33][CH2:34][NH:35][C:36]([O:38][C:39]([CH3:42])([CH3:41])[CH3:40])=[O:37])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 21906330HCID 21906330, compoundHCID 57936530HCID 57936530, compound

Product 1

HCID 68532681HCID 68532681, compoundYield 44%

Procedure

Using a procedure analogous to Example 4-E, N-(5-chloropyridin-2-yl)-4-fluoro-2-aminobenzamide and 4-(ethylthio)-2-(3-(t-butoxycarbonylamino)propyloxy)benzoic acid gave the title compound as a solid (0.93 g, 44%).

Sources & evidence

ORD record
ord-20106a472c844870a99166ecc782815c
Source dataset
uspto-grants-2010_04
Patent number
US07700628B2

Reaction notes

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