Hydrochloric Acid → HCID 68535253, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of N-(5-chloropyridin-2-yl)-4-methoxycarbonyl-2-[4-methylthio-2-(3-aminopropoxy)benzoylamino]benzamide (480 mg, 0.91 mmol), MeOH (10 mL) and water (7 mL) was added LiOH (109 mg, 4.54 mmol). The reaction mixture was heated to 65° C. for 45 min and then cooled to room temperature. To the mixture was added 5N HCl (1.8 mL, 9 mmol), and the resulting solid was filtered with CH2Cl2 and 20% Et2O/hexanes washes to give the title compound as a white solid (213 mg, 55%).

Provenance & Evidence