HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(1-tert-Butoxycarbonylpiperidin-4-yloxy)-4-(methylthio)benzoic acid → n-(5-Chloropyridin-2-yl)-4-iodo-2-[4-methylthio-2-(1-t-butoxycarbonylpiperidin-4-yloxy)benzoylamino]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(1-tert-Butoxycarbonylpiperidin-4-yloxy)-4-(methylthio)benzoic acid | HCID 11559684 | — |
| Reactant | N-(5-chloropyridin-2-yl)-4-iodo-2-aminobenzamide | HCID 68535003 | — |
| Product | n-(5-Chloropyridin-2-yl)-4-iodo-2-[4-methylthio-2-(1-t-butoxycarbonylpiperidin-4-yloxy)benzoylamino]benzamide | HCID 68533929 | 84% |
Reaction Steps
Using a procedure analogous to Example 4-E, N-(5-chloropyridin-2-yl)-4-iodo-2-aminobenzamide and 4-methylthio-2-(1-t-butoxycarbonylpiperidin-4-yloxy)benzoic acid gave the title compound as a white solid (3.03 g, 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-8b1af64b1a7c4466b6cce39d39b98971 |
| Source note | uspto-grants-2010_04 |