HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate → Methyl 2-(1-tert-butoxycarbonylpiperidin-3-ylmethoxy)-4-tert-butylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate | HCID 2763851 | — |
| Reactant | Methyl 4-tert-butyl-2-hydroxybenzoate | HCID 20777194 | — |
| Product | Methyl 2-(1-tert-butoxycarbonylpiperidin-3-ylmethoxy)-4-tert-butylbenzoate | HCID 68534336 | 32.1% |
Reaction Steps
In a manner substantially equivalent to Example 21-C, methyl 4-tert-butyl-2-hydroxybezoate (2.08 g, 10.0 mmol) and 1-Boc-3-hydroxymethylpiperidine (2.15 g, 10.0 mmol) were reacted to give the desired product (1.30 g, 32.1%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07700628B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-1873bcee984d44faad1cfff66b577b01 |
| Source note | uspto-grants-2010_04 |