反应详情

Methyl 4-benzyloxy-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoate was prepared from methyl 4-benzyloxy-2-hydroxybenzoate and 1-Boc-4-hydroxypiperidine using a procedure similar to that described in Example 21-C. The crude material, in dichloromethane, was filtered and purified by chromatography over silica gel using a preparative high pressure chromatography apparatus, eluting with a gradient of 9:1 to 4:1 to 3:1 hexane:ethyl acetate to give 12.8 g of a white solid.

1. filtrationThe crude material, in dichloromethane, was filtered
2. custompurified by chromatography over silica gel using a preparative high pressure chromatography apparatus
3. washeluting with a gradient of 9:1 to 4:1 to 3:1 hexane