反应详情

A mixture of 7.8 g (21.2 mmol) of (R)-2-amino-3-(3,4-diethyl-phenyl)-N-((1S,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-propionamide, 50 mL of water and 50 mL of 1,4-dioxane was refluxed for 7 days. The reaction mixture was evaporated down under reduced pressure, the residue remaining was stirred with EtOH and suction filtered. The desired product was obtained in the form of a white solid.

1. temperaturewas refluxed for 7 days
2. customThe reaction mixture was evaporated down under reduced pressure
3. filtrationfiltered