反应详情

The crude product (6 g, 11.84 mmol) described in 7a) was placed in 120 mL MeOH, combined with 40 mL 1M NaOH (40 mmol) and refluxed for 5 h. The reaction mixture was concentrated by evaporation in vacuo, the residue was combined with 150 mL of water and 40 mL 1M HCl, exhaustively extracted with DCM and the combined organic phases were dried over MgSO4. After elimination of the desiccant and solvent the residue was triturated with diisopropylether and suction filtered.

1. temperaturerefluxed for 5 h
2. concentrationThe reaction mixture was concentrated by evaporation in vacuo
3. extractionexhaustively extracted with DCM
4. dry with materialthe combined organic phases were dried over MgSO4
5. customAfter elimination of the desiccant and solvent the residue was triturated with diisopropylether and suction
6. filtrationfiltered