反应详情

To a solution of 650 mg of tert-butyl (2E)-3-(3-formyl-2-thienyl)acrylate in 15 ml of methanol was added 150 mg of 10% palladium-carbon, followed by stirring for 5 hours under a hydrogen atmosphere. After filtration through Celite, the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 530 mg of tert-butyl 3-(3-formyl-2-thienyl)propanoate.

1. filtrationAfter filtration through Celite
2. customthe solvent was evaporated under reduced pressure
3. customThe obtained residue was purified by silica gel column chromatography