8-Methyl-3-piperazin-1-yl-8-aza-bicyclo[3.2.1]octane trihydrochloride → 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-{(R)-1-(3,4-diethyl-benzyl)-2-[4-(8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-piperazin-1-yl]-2-oxo-ethyl}-amide
Reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:11][C@@H:12]([NH:16][C:17]([N:19]2[CH2:24][CH2:23][CH:22]([N:25]3[CH2:31][CH2:30][C:29]4[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=4[NH:27][C:26]3=[O:36])[CH2:21][CH2:20]2)=[O:18])[C:13](O)=[O:14])[CH:6]=[CH:7][C:8]=1[CH2:9][CH3:10])[CH3:2].Cl.Cl.Cl.[CH3:40][N:41]1[CH:46]2[CH2:47][CH2:48][CH:42]1[CH2:43][CH:44]([N:49]1[CH2:54][CH2:53][NH:52][CH2:51][CH2:50]1)[CH2:45]2>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:8]=1[CH2:9][CH3:10])[CH2:11][C@@H:12]([NH:16][C:17]([N:19]1[CH2:24][CH2:23][CH:22]([N:25]2[CH2:31][CH2:30][C:29]3[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=3[NH:27][C:26]2=[O:36])[CH2:21][CH2:20]1)=[O:18])[C:13]([N:52]1[CH2:53][CH2:54][N:49]([CH:44]2[CH2:45][CH:46]3[N:41]([CH3:40])[CH:42]([CH2:48][CH2:47]3)[CH2:43]2)[CH2:50][CH2:51]1)=[O:14])[CH3:2]Participants
3
Reactant 2
Product 1
Procedure
Prepared analogously to Example 9i) from 400 mg (0.81 mmol) (R)-3-(3,4-diethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid and 320 mg (1.00 mmol) 8-methyl-3-piperazin-1-yl-8-aza-bicyclo[3.2.1]octane trihydrochloride.
Sources & evidence
- ORD record
- ord-16d6d53fc1954b78b75d571603fd51ee
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07700589B2
Reaction notes
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