3-(Dimethylamino)piperidine → 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylic acid-[(R)-1-(3,4-diethyl-benzyl)-2-(3-dimethylamino-piperidin-1-yl)-2-oxo-ethyl]-amide

Participants

Reaction Steps

Prepared analogously to Example 9i) from 400 mg (0.81 mmol) (R)-3-(3,4-diethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid and 130 mg (1.01 mmol) dimethyl-piperidin-3-yl-amine.

Provenance & Evidence