HRID644326

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID28283030

1-(Piperidin-4-yl)-4-(propan-2-yl)piperazine

C12H25N3

结构：CCc1ccc(C[C@@H](NC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)O)cc1CC

HCID68579001

未命名化合物

PRODUCTS

生成物

结构：CCc1ccc(C[C@@H](NC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCN(C(C)C)CC3)CC2)cc1CC

HCID10439596

未命名化合物

PROCEDURE

实验过程

Prepared analogously to Example 9i) from 400 mg (0.81 mmol) (R)-3-(3,4-diethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid and 210 mg (0.99 mmol) 1-isopropyl-4-piperidin-4-yl-piperazine.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8fcc42019c2049278addcac2c27a29c9
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07700589B2
来源说明: uspto-grants-2010_04

反应 SMILES

[CH2:1]([C:3]1[CH:4]=[C:5]([CH2:11][C@@H:12]([NH:16][C:17]([N:19]2[CH2:24][CH2:23][CH:22]([N:25]3[CH2:31][CH2:30][C:29]4[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=4[NH:27][C:26]3=[O:36])[CH2:21][CH2:20]2)=[O:18])[C:13](O)=[O:14])[CH:6]=[CH:7][C:8]=1[CH2:9][CH3:10])[CH3:2].[CH:37]([N:40]1[CH2:45][CH2:44][N:43]([CH:46]2[CH2:51][CH2:50][NH:49][CH2:48][CH2:47]2)[CH2:42][CH2:41]1)([CH3:39])[CH3:38]>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:8]=1[CH2:9][CH3:10])[CH2:11][C@@H:12]([NH:16][C:17]([N:19]1[CH2:24][CH2:23][CH:22]([N:25]2[CH2:31][CH2:30][C:29]3[CH:32]=[CH:33][CH:34]=[CH:35][C:28]=3[NH:27][C:26]2=[O:36])[CH2:21][CH2:20]1)=[O:18])[C:13]([N:49]1[CH2:48][CH2:47][CH:46]([N:43]2[CH2:42][CH2:41][N:40]([CH:37]([CH3:39])[CH3:38])[CH2:45][CH2:44]2)[CH2:51][CH2:50]1)=[O:14])[CH3:2]